Cross-immunizing antigen vaccine and method for preparation thereof
AssigneeGreen BioMed, Inc.
InventorKenji Sekikawa
Life of this patent
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Abstract
The present invention provides a fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, containing antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity: (a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus; and (b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus (wherein the antigen(s) or the fragment(s) thereof of (a) and/or (b) have an oligomerization activity, or the fusion polypeptide further contains (c) a polypeptide having an oligomerization activity in addition to the antigens or the fragments thereof (a) and (b)).
Claims9
A fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, comprising antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity:
- (a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus;
- and
- (b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus,
- wherein the antigen or the fragment thereof of (a) is head-lacking hemagglutinin,
- wherein the antigen or the fragment thereof of (b) is a matrix protein 1 or a fragment thereof and comprises the amino acid sequence shown in SEQ ID NO:
- 3, and
- wherein the antigen or the fragment thereof of (b) has an oligomerization activity.
Dependencies are inferred from the claim text.