Burkholderia pseudomallei complex outer membrane vesicles as adjuvants
AssigneeThe Administrators of the Tulane Educational Fund
InventorsLisa Ann Morici, James B. McLachlan, Christopher J. H. Davitt, Jonathan R. Kurtz
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Abstract
Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be used as adjuvants in compositions and methods to potentiate the immune response to immunogens.
Claims47
An immunogenic composition, said composition comprising (a) a non-Burkholderia immunogen and (b) a plurality of outer membrane vesicles (OMVs) derived from one or more organisms of the species Burkholderia pseudomallei, B. mallei, B. oklahomensis, B. thailandensis, B. humptydooensis, or Burkholderia spp. Clades A, B, or C (collectively, the “B. pseudomallei complex” or “Bpc”).
A method of increasing a subject's immune response to a non-Burkholderia immunogen, said method comprising co-administering to said subject (a) an effective amount of a non-Burkholderia immunogen and (b) an effective amount of outer membrane vesicles (OMVs) of one or more species selected from the group consisting of Burkholderia pseudomallei, B. mallei, B. oklahomensis, B. thailandensis, B. humptydooensis, Burkholderia spp. Clade A, Burkholderia spp. Clade B, and Burkholderia spp. Clade C (collectively, “B. pseudomallei complex” or “Bpc”).
Dependencies are inferred from the claim text.