Adrenocorticotropic hormone-based pharmaceutical formulations and methods for fabricating and using thereof

A method for fabricating a pharmaceutical composition, the method consisting of combining a quantity of corticotropin, ACTH of a non-animal derivation, with:

• (a) a quantity of at least one water-soluble viscosity enhancing agent,
• (b) mannitol,
• (c) methionine,
• (d) optionally, an inactive component selected from the group consisting of a non-ionic poly(oxyethylene-co-oxypropylene) block copolymer, a polyoxyethylene sorbitan monolaurate, a polyoxyethylene sorbitan monopalmitate, a polyoxyethylene sorbitan monostearate, and a polyoxyethylene sorbitan monooleate;
• (e) optionally, hydrochloric acid;
• and
• (f) water,
• wherein the composition is free of gelatin and free of preservatives, wherein the methionine has a concentration of about 2 mg/mL to about 3 mg/mL, wherein the composition has a pH of 4.0-6.5, wherein the corticotropin comprises a recombinant polypeptide, and wherein the composition is potent for at least 180 days.