Use of peptide compounds in treating acute pancreatitis
AssigneeShenzhen HighTide Biopharmaceutical, Ltd.
InventorsLiping Liu, Ru Bai
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Abstract
This invention discloses certain methods of treating acute pancreatitis and inflammatory pancreatic disease or condition. The disclosed peptides and analogs can significantly lower the elevated blood amylase and lipase levels caused by acute pancreatitis and pancreatic inflammation, reduce the degree of injury observed in pancreatic histopathology caused by pancreatitis, and significantly lower the mortality rate of acute pancreatitis.
Claims3
A method for treating inflammatory pancreatic disease or condition comprising administering to a patient in need thereof a pharmaceutical composition comprising an islet neogenesis associated protein (INGAP-PP) peptide, selected from the group consisting of:
- TABLE 2
- INGAP-PP
- Peptide ID/
- SEQ ID NO.
- Sequence
- 1
- H-IGLHDPSHGTLPNGS-OH
- 6
- H-IGLHAPSHGTLPNGS-OH
- 7
- H-IGLHDPSHGTLPAGS-OH
- 8
- H-IGLHAPSHGTLPAGS-OH
- 9
- H-IGLHDPSHGTLPAGSK-OH
- 10
- H-IGLHDPSHGTLP(Aib)GS-OH
- 11
- H-IGLHDPSHGTLP(N-methyl-L-Alanine)
- GS-OH
- 12
- Ac-IGLHDPSHGTLPAGS-OH
- 13
- H-(D-Isoleucine)GLHDPSHGTLPAGS-OH
- 14
- H-(L-NorValine)GLHDPSHGTLPAGS-OH
- 15
- H-(L-NorLeucine)GLHDPSHGTLPAGS-OH
- 16
- Ac-IGLHDPSHGTLPNGS-OH
- 17
- H-(D-Isoleucine)GLHDPSHGTLPNGS-OH
- 18
- H-IGLHDPSHGTEPNGS-OH
- 19
- H-IGLHDPSQGTLPNGS-OH
- 20
- H-IGLHDPTHGTLPNGS-OH
- 21
- H-IGLHDPSHGTLPNGE-OH
- 22
- H-IGLHDPSHGTLPNGK-OH
- 23
- H-IGLHDPSHGTLPAGK-OH
- 24
- H-IGLHDPSHGTEPAGS-OH
- 25
- H-IGLHDPSQGTLPAGS-OH
- 26
- H-IGLHDPTHGTLPAGS-OH
- 27
- H-IGLHDPSHGTLPAGE-OH
- 28
- H-IGLHDPSHGTLPAG-NH2
- 29
- Ac-IGLHDPSHGTLPAGS-NH2
- 30
- Ac-IGLHDPSHGTLPAG-NH2
- 31
- Ac-IGLHDPSHGTLPNGS-NH2
- 32
- H-IGLHDPSHGTLPNGS-NH2
- 33
- H-IGLHDPSHGTLPNGSC-OH
- 34
- Ac-IGLHDPSHGTLPNGSC-OH
- 35
- H-IGLHDPSHGTLPNGSC-NH2
- 36
- Ac-IGLHDPSHGTLPNGSC-NH2
- 37
- H-IGLHDPSHGTLPNGC-OH
- 38
- Ac-IGLHDPSHGTLPNGC-OH
- 39
- H-IGLHDPSHGTLPNGC-NH2
- 40
- Ac-IGLHDPSHGTLPNGC-NH2
- 41
- H-IGLHDPSHGTLPAGS-NH2
- 42
- H-IGLHDPSHGTLPAGSC-OH
- 43
- Ac-IGLHDPSHGTLPAGSC-OH
- 44
- H-IGLHDPSHGTLPAGSC-NH2
- 45
- Ac-IGLHDPSHGTLPAGSC-NH2
- 46
- H-IGLHDPSHGTLPAGC-OH
- 47
- Ac-IGLHDPSHGTLPAGC-OH
- 48
- H-IGLHDPSHGTLPAGC-NH2
- 49
- Ac-IGLHDPSHGTLPAGC-NH2
- 73
- IGLHDPSHGTLPAG
- 74
- IGLHDPSHGTLPNG
- 75
- Ac-IGLHDPSHGTLPNG
- 76
- IGLHDPSHGTLPNG-NH2
- 77
- Ac-IGLHDPSHGTLPNG-NH2
- 78
- H-IGLHDPSHGTLPQGS-OH
- 79
- H-IGLHDPSHGTLPDGS-OH
- 80
- H-IGLHDPSHGTLPEGS-OH
- 81
- H-IGLHEPSHGTLPNGS-OH
- 82
- H-IGLHQPSHGTLPNGS-OH
- 83
- H-IGLHNPSHGTLPNGS-OH
- 84
- H-IGLHEPSHGTLPAGS-OH
- 85
- H-IGLHQPSHGTLPAGS-OH
- 86
- H-IGLHNPSHGTLPAGS-OH
- 87
- H-IGLHDPSHGTLPQGSC-OH
- 88
- H-IGLHDPSHGTLPDGSC-OH
- 89
- H-IGLHDPSHGTLPEGSC-OH
- 90
- H-IGLHEPSHGTLPNGSC-OH
- 91
- H-IGLHQPSHGTLPNGSC-OH
- 92
- H-IGLHNPSHGTLPNGSC-OH
- 93
- H-IGLHDPSHGTLPQG-OH
- 94
- H-IGLHDPSHGTLPDG-OH
- 95
- H-IGLHDPSHGTLPEG-OH
- 96
- H-IGLHEPSHGTLPNG-OH
- 97
- H-IGLHQPSHGTLPNG-OH
- 98
- H-IGLHNPSHGTLPNG-OH
- 99
- H-IGLHEPSHGTLPAG-OH
- 100
- H-IGLHQPSHGTLPAG-OH
- 101
- H-IGLHNPSHGTLPAG-OH
- 102
- H-IGLHDPSHGTLPQGE-OH
- 103
- H-IGLHDPSHGTLPDGE-OH
- 104
- H-IGLHDPSHGTLPEGE-OH
- 105
- H-IGLHEPSHGTLPNGE-OH
- 106
- H-IGLHQPSHGTLPNGE-OH
- 107
- H-IGLHNPSHGTLPNGE-OH
- 108
- H-IGLHEPSHGTLPAGE-OH
- 109
- H-IGLHQPSHGTLPAGE-OH
- 110
- H-IGLHNPSHGTLPAGE-OH
- wherein the treatment results in pathological improvement in pancreatic edema, inflammation, hemorrhage and necrosis.
Dependencies are inferred from the claim text.