Carbohydrate-based peritoneal dialysis fluid comprising glutamine residue
AssigneeZytoprotec GmbH
InventorChristoph Aufricht
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Abstract
The present invention relates to a carbohydrate-based peritoneal dialysis fluid, containing a compound selected from the group consisting of glutamine, preferably L-glutamine; a dipeptide capable of releasing glutamine, L-glutamine in free form, preferably selected from the group consisting of glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine, alanyl-glutamine; an oligopeptide consisting of two to seven glutamine, preferably L-glutamine residues; and mixtures thereof. The peritoneal dialysis fluids of the present invention are useful for inhibition of technical failure in a person undergoing peritoneal dialysis treatment.
Claims3
A method for inhibiting technical failure in a patient in need of peritoneal dialysis, comprising treating said patient with a glucose-based peritoneal dialysis fluid comprising,
- glucose and
- a dipeptide that is glutaminyl-glycine, glycinyl-glutamine, glutaminyl-alanine or alanyl-glutamine, or a mixture of two or more of said dipeptides wherein the concentration of said dipeptide in the dialysis fluid is 2 mM to 25 mM
- wherein the glucose concentration in the dialysis fluid is 10 g/l to 45 g/l, and
- wherein the glucose-based peritoneal dialysis fluid does not include glutamine in its monomeric form and
- wherein the glucose-based peritoneal dialysis fluid contains only amino acids in dipeptide form.
A method for inhibiting technical failure in a patient in need of peritoneal dialysis, comprising treating said patient with a glucose-based peritoneal dialysis fluid consisting essentially of:
- a peritoneal dialysis fluid comprising glucose;
- and a dipeptide that is glutaminyl-glycine, glycinyl-glutamine, glutamine-alanine or alanyl-glutamine, or a mixture of two or more of said dipeptides, wherein the concentration of said dipeptide in the dialysis fluid is 2 mM to 25 mM,
- wherein the glucose concentration in the dialysis fluid is 10 g/l to 45 g/l and
- wherein the glucose-based peritoneal dialysis fluid only contains amino acids in dipeptide form.
Dependencies are inferred from the claim text.