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US 11,534,466 B2Granted
Pancreatic stem cells and uses thereof
AssigneeAal Scientifics, Inc.
InventorPiero Anversa
Life of this patent
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Abstract
The disclosure relates to stem cells and their therapeutic use in the treatment and/or prevention of pancreatic diseases or disorders. Provided herein are compositions comprising c-kit positive pancreatic stem cells and methods of preparing and using c-kit positive pancreatic stem cells for the treatment and/or prevention of pancreatic diseases or disorders.
Claims11
A pharmaceutical composition comprising:
- a therapeutically effective amount of isolated and in vitro expanded adult pancreatic stem cells and a pharmaceutically acceptable carrier for repairing and/or regenerating damaged tissue of a pancreas;
- wherein said isolated and expanded pancreatic stem cells are c-kit positive, negative for hematopoietic cell lineage marker CD45, negative for mesenchymal stromal cell epitope CD90, clonogenic, multipotent, and self-renewing;
- wherein said isolated and expanded adult pancreatic stem cells migrate to non-pathological and pathological portions of the pancreas, generate beta cells and produce insulin in vivo;
- and
- wherein said pharmaceutical composition does not comprise a majority of cells that are both c-kit positive and tryptase-positive.
2 more elements
Dependencies are inferred from the claim text.