Fecal matter for treatment of autoimmune diseases
AssigneeAcademisch Medisch Centrum
InventorsMax Nieuwdorp, Willem Meindert De Vos
Life of this patent
Estimating the term…
Abstract
The use of fecal matter in the treatment of a subject having autoimmune disease, wherein the fecal matter is autologous to the subject, and preferably administered to the small intestine, preferably the duodenum, of the subject. The fecal matter can be one or more constituents of autologous feces, preferably chosen from the group consisting of bacteria, viruses, bacteriophages, fungi, metabolites, microRNAs, proteins, antibodies, and/or antigens.
Claims23
A method of treating an autoimmune disease in a subject, the method comprising:
- administration to the subject of feces that is autologous to the subject,
- wherein the autoimmune disease is type 1 diabetes mellitus, Hashimoto's disease, Graves' disease, Addison's disease, psoriasis, vitiligo, rheumatoid arthritis, Bechterew's disease, celiac disease, or asthma, and
- wherein the feces is obtained from the subject while having the autoimmune disease.
A method of treating a subject diagnosed as having an autoimmune disease, the method comprising:
- administering feces autologous to the subject,
- wherein the autoimmune disease is type 1 diabetes mellitus, Hashimoto's disease, Graves' disease, Addison's disease, psoriasis, vitiligo, rheumatoid arthritis, Bechterew's disease, celiac disease, or asthma,
- wherein the administration of autologous feces is to the subject's small intestine, and
- wherein the feces has been obtained from the subject while having the autoimmune disease.
A method of treating a subject for an autoimmune disease selected from the group consisting of type 1 diabetes, Hashimoto's disease, Graves' disease, Addison's disease, psoriasis, vitiligo, rheumatoid arthritis, Bechterew's disease, celiac disease, and asthma, the method comprising:
- administering to the subject feces that is autologous to the subject,
- wherein the feces is obtained from the subject while having the autoimmune disease,
- wherein the feces is obtained by mixing autologous feces with an aqueous medium and subsequent filtering and/or centrifugation of the mixture, and
- wherein the feces is comprised in liquid medium and/or does not comprise solids having a diameter of more than 1000 μm.
Dependencies are inferred from the claim text.