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US 11,534,464 B2Granted
Direct reprogramming of cells to cardiac myocyte fate
AssigneeDuke University
InventorsVictor J. Dzau, Maria Mirotsou, Tilanthi Jayawardena
Life of this patent
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Abstract
A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.
Claims10
A medical device comprising a purified population of primary cells comprising an exogenous mir construct or combination of constructs selected from the group consisting of mir1;
- mir133;
- mir138;
- mir206;
- mir208;
- mir126;
- mir1, mir133;
- mir1, mir138;
- mir1,mir206;
- mir1, mir208;
- mir133, mir138;
- mir133, mir206;
- mir133, mir208;
- mir138, mir206;
- mir138, mir208;
- mir206, mir208;
- mir1, mir138, mir208;
- mir1, mir206, mir208;
- mir138, mir206, mir208;
- mir1, mir133, mir206;
- mir1, mir133, mir208;
- mir1, mir138, mir206;
- mir133, mir138, mir208;
- and mir133, mir138, mir206;
- mir1, mir133, mir208, mir499-5p;
- mir1, mir133, mir206, mir499-5p;
- and mir499-5p.
23 more elements
Dependencies are inferred from the claim text.