US 11,534,452 B2 · Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection

Abstract

A method for identifying a compound that prevents, ameliorates and/or inhibits a hepatitis B virus (HBV) infection is provided, wherein a compound that reduces the expression and/or activity of PAP associated domain containing 5 (PAPD5) and/or PAP associated domain containing 7 (PAPD7) is identified as a compound that prevents, ameliorates and/or inhibits a HBV infection. Inhibitors of PAPD5 or PAPD7 are provided for use in treating and/or preventing a HBV infection; as well as a combined preparation comprising an inhibitor of PAPD5 and an inhibitor of PAPD7 for simultaneous or sequential use in the treatment or prevention of a HBV infection.

Claims18

Dependent claims

A method for the treatment of Hepatitis B virus infection in a subject, said method comprising administering an effective amount of a composition comprising a nucleic acid molecule which directly inhibits expression and/or activity of PAP associated domain containing 5 (PAPD5) to the subject;

wherein the nucleic acid molecule is independently selected from the group consisting of:
a. single stranded antisense oligonucleotide;
b. siRNA molecule;
and
c. shRNA molecule.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/310,789Filed 19 Jun 2017

Priority

EP 1617504517 Jun 2016

Published

US 2019/0216846 A118 Jul 2019

Granted

27 Dec 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 31/7125
Compounds having three or more nucleosides or nucleotides: nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other…
A61K 31/4745
Ortho- or peri-condensed with heterocyclic ring systems: condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
A61K 31/519
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim: ortho- or peri-condensed with heterocyclic rings
A61P 31/14
Antivirals: for RNA viruses

Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection

Life of this patent

Nucleic acid molecules for reduction of PAPD5 or PAPD7 mRNA for treating hepatitis B infection

Life of this patent

Abstract

Claims18