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US 11,534,450 B2Granted
Methods and compositions for the activation of gamma-delta T-cells
AssigneeAmerican Gene Technologies International Inc.
InventorsCharles David Pauza, Haishan Li, Tyler Lahusen, Mei-Ling Liou
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Abstract
The present invention relates generally to methods and compositions for gene therapy and immunotherapy that activate gamma delta T-cells, and in particular, can be used in the treatment of various cancers and infectious diseases.
Claims20
A method of activating a GD T cell comprising:
- contacting a target cell with a bisphosphonate drug;
- and
- infecting, in the presence of the GD T cell, the target cell with a viral delivery system that encodes at least one genetic element comprising a small RNA capable of inhibiting production of FDP S,
- wherein the GD T cell is activated.
1 more element
A method of activating a lymphocyte cell comprising:
- contacting a target cell with a bisphosphonate drug;
- and
- infecting, in the presence of the lymphocyte cell, the target cell with a viral delivery system that encodes at least one genetic element comprising a small RNA capable of inhibiting production of an enzyme of the mevalonate pathway,
- wherein the lymphocyte cell is activated.
1 more element
Dependencies are inferred from the claim text.