Tricin derivatives and compositions thereof for cancer treatment
AssigneeNeocage Sl
InventorsManuel Gidekel, Jose Luis Novella Robisco, Mario Nicolas Banduc
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Abstract
Provided are compositions and methods for treatment of cancer and for adoptive T cell therapy (ACT). The compositions comprise one or more derivatives of tricin 7-O-β-D-glucopyranoside (ANTARTINA®). The compositions comprise one or more pharmaceutically acceptable excipients convenient for delivery of the tricin 7-O-β-D-glucopyranoside derivatives. Tricin 7-O-β-D-glucopyranoside derivatives described herein include acetylated tricin 7-O-β-D-glucopyranoside, as well as glucose, maltose, cellobiose, lactose, xylose, and galactose derivatives. The methods include treatment, or reduction in the risk of suffering from, colorectal cancer and hepatocellular cancer.
Claims10
A method of treating colorectal cancer or hepatocellular carcinoma in a subject in need thereof, which comprises:
- administering a pharmaceutically effective composition comprising one or more derivatives of tricin 7-O-β-D-glucopyranoside,
- wherein the one or more derivatives of tricin 7-O-β-D-glucopyranosidc is one or more of:
- hexa-acylated tricin 7-O-β-D-glucopyranoside (6a),
- [3,4,5-triacetoxy-6-[5-hydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)-4-oxo-chromen-7-yl]oxy-tetrahydropyran-2-yl]methyl acetate (5b),
- xylose tricin 7-O-β-D-glucopyranoside (1c),
- 7-[(3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxyrnethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)chromen-4-one (1d),
- 7-[(3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5-hydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)chromen-4-one (1e), and
- 7-[(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-tetrahydropyran-2-yl]oxy-5hydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)chromen-4-one.
A method of reducing proliferation of colorectal cancer cells or hepatocellular carcinoma cells, and/or reducing size of a tumor, wherein the method comprises administering to the subject in need thereof a pharmaceutically effective amount of hexa-acylated tricin 7-O-β-D-glucopyranoside (6a).
Dependencies are inferred from the claim text.