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US 11,534,446 B2Granted
Pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one with improved storage and solubility properties
AssigneeAsarina Pharma AB
InventorsTorbjörn Bäckström, Anders Carlsson
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Abstract
It is provided a pharmaceutical composition comprising 3-beta-hydroxy-5-alpha-pregnan-20-one, at least one sterol or an ester thereof and a mixture of acylglycerols with a solid fat content of less than 25% at 25° C. and 0% at 37° C. In addition it is provided a method for preparing the pharmaceutical composition.
Claims19
A pharmaceutical composition, comprising:
- 3-beta-hydroxy-5-alpha-pregnan-20-one;
- cholesterol;
- and
- a medium-chain triacylglycerol (MCT),
- wherein a weight ratio of said cholesterol to said 3-beta-hydroxy-5-alpha-pregnan-20-one is 1:5 to 2:1,
- wherein 3-beta-hydroxy-5-alpha-pregnan-20-one is present in an amount of up to 75 mg/g of the composition;
- and
- wherein at room temperature the composition is a liquid oil composition.
5 more elements
Dependencies are inferred from the claim text.