Quinazoline compounds, preparation method, use, and pharmaceutical composition thereof

A compound represented by Formula (IV), or a stereoisomer, a geometric isomer, a tautomer or a pharmaceutically acceptable salt thereof:

• wherein,
• R4 is C1-3 alkyl;
• L is selected from a single bond or C1-3 alkylene, wherein said C1-3 alkylene is optionally substituted with one or more Ra;
• Ra is selected from hydrogen, halogen or C1-3 alkyl;
• R1 is selected from hydrogen, C1-3 alkyl, C1-3 alkoxy, 3- to 7-membered cycloalkyl, 3- to 7-membered heterocycloalkyl or 5- to 6-membered heteroaryl, when R1 is not hydrogen, it is optionally substituted with m R6;
• m is 0, 1, 2, 3 or 4;
• each R6 is independently selected from halogen, cyano, hydroxyl, trifluoromethyl, C1-3 alkyl, C1-3 alkoxy, C1-3 hydroxyalkyl, C1-3 alkylamino or di(C1-3 alkyl)amino;
• R2 is selected from C1-3 alkoxy, halogen or C1-3 alkyl;
• and
• R3 is selected from C1-3 alkyl, 3- to 7-membered cycloalkyl, 6- to 10-membered aryl or 5- to 6-membered heteroaryl, wherein said 6- to 10-membered aryl and 5- to 6-membered heteroaryl are optionally substituted with one or more groups independently selected from hydrogen, halogen, C1-3 alkyl, amino, C1-3 alkylamino, di(C1-3 alkyl)amino, trifluoromethyl, difluoromethyl, cyano or C1-3 alkoxy.