Methods of treating radiation induced gastrointestinal syndrome (RIGS) and related disease states using compound 512
AssigneeBCN Biosciences L.L.C.
InventorAndrew J. Norris
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Abstract
The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, mucositis, e.g., oral mucositis, and proctitis by the administration of compound 512, or an analog thereof.
Claims12
A method of treating chemotherapy induced injury or radiation induced injury of the GI tract in a subject in need thereof, the method comprising the step of administering to the subject a therapeutically effective amount of a compound of Formula IIA:
A method of treating chemotherapy induced injury or radiation induced injury of the GI tract in a subject in need thereof, the method comprising the step of administering to the subject a therapeutically effective amount of an analog of Formula IIA, wherein the analog is selected from the group consisting of Formula IIC, Formula IID, Formula IIE and Formula IIB:
- wherein Y1 and Y2 taken together with X form:
- wherein X is N, G is N, Z is absent or selected from substituted or unsubstituted alkyl, heteroalkyl, alkenyl, or alkynyl,
- wherein R4 is absent or selected from substituted or unsubstituted aryl;
- and
- wherein R5 and R6 are each independently absent or lower alkyl.
Dependencies are inferred from the claim text.