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US 11,534,430 B2Granted
Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
AssigneeLutonix, Inc.
InventorLixiao Wang
Life of this patent
Estimating the term…
Abstract
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and an additive.
Claims19
A balloon catheter comprising:
- a coating layer overlying an exterior surface of a balloon of the balloon catheter;
- and
- an adherent layer between the exterior surface and the coating layer,
- wherein:
- the balloon catheter is sized and configured for insertion into a passage of a respiratory system;
- the adherent layer adheres the coating layer directly to the exterior surface of the balloon catheter;
- the coating layer comprises a water insoluble drug and a combination of a first additive and a second additive;
- the water insoluble drug is chosen from paclitaxel and rapamycin;
- the first additive is chosen from PEG laurate, PEG oleate, PEG stearate, PEG glyceryl laurate, PEG glyceryl oleate, PEG glyceryl stearate, polyglyceryl laurate, polyglyceryl oleate, polyglyceryl myristate, polyglyceryl palmitate, PEG-20 sorbitan monolaurate, PEG-20 sorbitan monopalmitate, PEG-20 sorbitan monostearate, and PEG-20 sorbitan monooleate, PEG sorbitan stearate, or combinations thereof;
- and
- the second additive is chosen from sorbitol, glucose, sucrose, lactobionic acid, gluconolactone, meglumine, lactic acid, gentisic acid, or combinations thereof.
8 more elements
A method for treating a respiratory system, the method comprising:
- inserting into an airway a balloon catheter comprising a coating layer overlying an exterior surface of the balloon of the balloon catheter and an adherent layer between the exterior surface and the coating layer, wherein:
- the adherent layer adheres the coating directly to the exterior surface of the balloon catheter;
- the coating layer comprises a drug, a first additive, and a second additive;
- the drug is chosen from paclitaxel and rapamycin,
- the first additive is chosen from PEG laurate, PEG oleate, PEG stearate, PEG glyceryl laurate, PEG glyceryl oleate, PEG glyceryl stearate, polyglyceryl laurate, polyglyceryl oleate, polyglyceryl myristate, polyglyceryl palmitate, PEG-20 sorbitan monolaurate, PEG-20 sorbitan monopalmitate, PEG-20 sorbitan monostearate, and PEG-20 sorbitan monooleate, PEG sorbitan stearate, or combinations thereof;
- and
- the second additive is chosen from sorbitol, glucose, sucrose, lactobionic acid, gluconolactone, meglumine, lactic acid, gentisic acid, or combinations thereof;
- inflating the balloon catheter and releasing the drug to a wall of the airway;
- deflating the balloon;
- and
- withdrawing the balloon catheter from the airway.
8 more elements
Dependencies are inferred from the claim text.