Compounds for the treatment of acute organ injury

A method to reduce organ injury resulting from an ischemic event, comprising administering to a patient in need thereof a compound having the formula:

• or a pharmaceutically acceptable salt thereof,
• wherein
• L1 is null;
• Rx1 is hydrogen;
• X is S;
• Rx2 is hydrogen;
• L2 is null;
• R1a is selected from F, Cl, Br, R1a′, OR1a′, or N(R1a′)2, wherein R1a′ is in each case independently selected from hydrogen or C1-8alkyl;
• R1b is selected from R1b′, OR1b′, or N(R1b′)2, wherein R1b′ is in each case independently selected from hydrogen or C1-8alkyl;
• R1c is selected from R1c′, OR1c′, or N(R1c′)2, wherein R1c′ is in each case independently selected from hydrogen or C1-8alkyl;
• R1d is selected from R1d′, OR1d′, or N(R1d′)2, wherein R1d′ is in each case independently selected from hydrogen or C1-8alkyl;
• Rx1a is selected from hydrogen or C1-8alkyl;
• Rx1c is selected from Rx1c′, ORx1c′, or N(Rx1c′)2, wherein Rx1c′ is in each case independently selected from hydrogen or C1-8alkyl;
• R2a is selected from R2a′, OR2a′, or N(R2a′)2, wherein R2a′ is in each case independently selected from hydrogen or C1-8alkyl;
• R2b is selected from R2b′, OR2b′, or N(R2b′)2, wherein R2b′ is in each case independently selected from hydrogen or C1-8alkyl;
• R2c is selected from R2c′, OR2c′, or N(R2c′)2, wherein R2c′ is in each case independently selected from hydrogen or C1-8alkyl;
• R2d is selected from R2d′, OR2d′, or N(R2d′)2, wherein R2d′ is in each case independently selected from hydrogen or C1-8alkyl;
• Rx2a is selected from H and C1-8alkyl;
• Rx2c is selected from Rx2c′, ORx2c′, or N(Rx2c′)2, wherein Rx2c′ is in each case independently selected from hydrogen or C1-8alkyl;
• and wherein the injured organ is the brain, heart, or kidney.