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US 11,534,423 B2Granted
Methods and compositions for improving exercise endurance, performance, or tolerance
AssigneeWashington University
InventorsRita Brookheart, Brian Finck
Life of this patent
Estimating the term…
Abstract
Among the various aspects of the present disclosure is the provision of methods and compositions for improving exercise endurance, performance, or tolerance using an S1P inhibiting agent.
Claims12
A method of improving exercise tolerance or enhancing exercise performance in a subject comprising:
- administering a pharmaceutical composition comprising a S1P inhibiting agent in an amount effective to reduce or deplete S1P levels or reduce or deplete S1P activity in the subject and improve exercise tolerance or enhance exercise performance compared to the subject prior to being administered the pharmaceutical composition, wherein the subject has a mutation in a gene encoding S1P (MBTPS1) that results in an increase in S1P protein that is expressed or an increase in activity of S1P target pathways compared to a subject having wild type MBTPS1.
A method of treating a disease, disorder, or condition associated with reduced exercise tolerance or endurance in a subject comprising
- administering a pharmaceutical composition comprising a S1P inhibiting agent in an amount effective to reduce or deplete S1P levels or reduce or deplete S1P activity in the subject and improve exercise tolerance or enhance exercise performance compared to the subject prior to being administered the pharmaceutical composition, wherein the subject has a mutation in a gene encoding S1P (MBTPS1) that results in an increase in S1P protein that is expressed or an increase in activity of S1P target pathways compared to a normal subject having wild type MBTPS1.
Dependencies are inferred from the claim text.