Methods and compositions for soft anticholinergic esters
AssigneeBodor Laboratories, Inc.
InventorNicholas S. Bodor
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Abstract
Intra-oral formulations comprising soft anticholinergic alkyl esters are useful for treating excessive drooling conditions in subjects, such as humans, suffering from sialorrhea. Preferably, at least one soft anticholinergic ester is provided in an effective amount or concentration in an anhydrous intra-oral formulation that can inhibit excessive drooling resulting from a condition known as sialorrhea.
Claims55
A method for treating sialorrhea in a subject suffering from same, said method comprising intra-orally administering at least one compound having the formula:
- wherein R is methyl or ethyl, said compound having the R stereoisomeric configuration at the 2 position and the R, S or RS stereoisomeric configuration at the 1′ and 3′ positions, or being a mixture thereof, to a subject suffering from sialorrhea, in an amount of compound of formula (2) of from about 1 mg to about 10 mg per adult dose, or from about 0.02 mg/kg to about 1.0 mg/kg per pediatric dose.
A method for treating sialorrhea in a pediatric subject suffering from same, said method comprising intra-orally administering at least one compound having the formula:
- wherein R is methyl or ethyl, said compound having the R stereoisomeric configuration at the 2 position and the R, S or RS stereoisomeric configuration at the 1′ and 3′ positions, or being a mixture thereof, to the pediatric subject suffering from sialorrhea, in an amount of compound of the at least one formula (2) of from about 0.02 mg/kg to about 1.0 mg/kg per pediatric dose.
Dependencies are inferred from the claim text.