Methods and agents that enhance myogenic progenitor cell engraftment
AssigneesPresident and Fellows of Harvard College, Children's Medical Center Corporation
InventorsSahar Tavakoli, Amy J. Wagers, Leonard Zon
Life of this patent
Estimating the term…
Abstract
Disclosed herein are agents that enhance muscle stem cell engraftment, as well as methods and compositions using the same.
Claims11
A method of increasing the engraftment efficiency of myogenic progenitor cells comprising contacting the myogenic progenitor cells with one or more agents that increase the engraftment efficiency of the myogenic progenitor cells into a subject, wherein the one or more agents are selected from the group consisting of a compound that increases intracellular Ca2+ levels in myogenic progenitor cells, meclofenamic acid (MFA) at a concentration of from about 1-50 uM, lysophosphatidic acid (LPA) at a concentration of from about 0.1-10 uM, and niflumic acid (NFA) at a concentration of from about 0.1 to 150 uM.
Dependencies are inferred from the claim text.