Microcapsules and methods of using the same
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsTagbo Herman Roland Niepa, Shanna-Leigh Davidson
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Abstract
The present disclosure relates to microcapsules, methods of using such microcapsules in the delivery of drugs and probiotic microbes to subjects in need thereof, and methods of using such microcapsules for in vitro culture of microbes. In particular, the microcapsules comprise novel siloxane-based membranes that maintains transport properties essential to communication and growth of microbes.
Claims14
A microcapsule comprising:
- (a) a membrane comprising a crosslinked polymer, wherein the crosslinked polymer comprises siloxane units, wherein the membrane comprises dimethylallylamine;
- and
- (b) a core comprising a plurality of microbes suspended in a medium,
- wherein the core is completely enclosed by the membrane.
A method for restoring a healthy microbiome in a subject, comprising administering to the subject a plurality of microcapsules comprising an effective amount of probiotic microbes,
- wherein each of the microcapsule comprises:
- (a) a membrane comprising a crosslinked polymer, wherein the crosslinked polymer comprises siloxane units;
- and (b) a core comprising a plurality of the probiotic microbes suspended in a medium, wherein the core is completely enclosed by the membrane, wherein the membrane comprises dimethylallylamine.
Dependencies are inferred from the claim text.