Thermo-responsive hydrogel for intratumoral administration as a treatment in solid tumor cancers
AssigneeRoyal College of Surgeons In Ireland
InventorsHelena Kelly, Garry Duffy, Seona Rossi, Conn Hastings
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Abstract
A room temperature injectable thermo-responsive hydrogel comprises a P407 poloxamer base hydrogel, chitosan, 2-Hydroxypropyl β-cyclodextrin and genipin. The chitosan and genipin form an interpenetrating scaffold within the hydrogel in which the chitosan is crosslinked with genipin. Chemotherapeutic drugs can be added to the hydrogel singly or in combination in effective amounts without any loss of thermo-responsiveness in the hydrogel. Therapeutic use of the thermo-responsive hydrogel in the intratumoural treatment of solid cancer is also described.
Claims12
A lyophilised hydrogel formed by lyophilising an uncured thermo-responsive hydrogel, the uncured thermo-responsive hydrogel comprising:
- 15-25% poloxamer P407 optionally in combination with poloxamer P188 (w/w);
- 0.1-1.0% chitosan (w/w);
- 0.05-0.20% genipin (w/w);
- 5-20% inclusion complexer (w/w);
- and
- an aqueous base.
Dependencies are inferred from the claim text.