Inhaled preparation of isoglycyrrhizic acid or salt thereof, and use in preparing drugs for treating respiratory system diseases
AssigneeChia Tai Tianqing Pharmaceutical Group Co., Ltd.
InventorsHongmei Gu, Shanchun Wang, Xiquan Zhang, Lei Huang, Hongjiang Xu, Wei Song, Ping Dong, Zhongying Sun, Ying Zhang, Deyang Chen
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Abstract
The present invention belongs to the field of medicine, relates to an inhaled preparation of isoglycyrrhizic acid or a salt thereof, and in particular relates to an inhaled preparation of magnesium isoglycyrrhizinate and the use thereof in preparing drugs for treating respiratory system diseases.
Claims10
A method for alleviating phlegm by administrating an inhaled preparation of magnesium isoglycyrrhizinate to a subject in need thereof, characterized in that the inhaled preparation delivers the magnesium isoglycyrrhizinate to lungs to exert a local or systemic effect,
- wherein the inhaled preparation is a liquid preparation for use in a nebulizer or powder fir inhalation,
- wherein the liquid preparation for use in a nebulizer comprising magnesium isoglycyrrhizinate, sodium chloride, ammonium hydroxide, and water for injection, with the pH of 6.5-7.0, the nebulizer being a continuous nebulizer or a quantitative nebulizer, the amount of the magnesium isoglycyrrhizinate being from 0.1 mg/ml to 5 mg/ml, and the amount of the sodium chloride being 9 mg/ml;
- wherein the powder for inhalation comprises magnesium isoglycyrrhizinate and one or more pharmaceutically acceptable carriers, the magnesium isoglycyrrhizinate being micronized and has a particle size of 0.5-10 μm, and the pharmaceutically acceptable carrier being ground lactose, sieved lactose or a mixture of sieved lactose and fine lactose, the particle size distribution of the ground lactose ranging from 1 to 350 μm, the particle size distribution of the sieved lactose ranging from 1 to 200 μm and the article size distribution of the time lactose ranges being from 1 to 60 μm, the ground lactose having a particle size distribution of X50 being 30-110 μm, the sieve lactose having a particle size distribution of X50 being 35-115 μm, and the fine lactose having a particle size distribution of X90<45 μm.
Dependencies are inferred from the claim text.