Solvent-free method of encapsulating a hydrophobic active
AssigneeAgency for Science, Technology and Research
InventorsPraveen Thoniyot, Parijat Kanaujia, Alexander M. Van Herk
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Abstract
Present disclosure relates to a solvent-free method of encapsulating a hydrophobic active in personal care, hydrophobic active in crop protection or a hydrophobic active pharmaceutical ingredient (API) in polymeric nanoparticles. The method includes mixing the hydrophobic active in a polymer melt, wherein the polymer melt comprises a melt of a block co-polymer, wherein the polymer melt acts as a solvent for the hydrophobic active. The method further includes maintaining the polymer melt in water for sufficient time to allow self-assembly of the block co-polymer to encapsulate the hydrophobic active therein.
Claims16
A solvent-free method of encapsulating a hydrophobic active in personal care, hydrophobic active in crop protection or a hydrophobic active pharmaceutical ingredient (API) in polymeric nanoparticles, the method comprising:
- mixing the hydrophobic active in a polymer melt, wherein the polymer melt consists of a melt of a block co-polymer, wherein the polymer melt acts as a solvent for the hydrophobic active;
- dispersing the polymer melt having the hydrophobic active solubilized therein in solely water;
- and
- maintaining the polymer melt in water for sufficient time to allow self-assembly of the polymeric nanoparticles spontaneously occurring in the polymer melt, wherein the self-assembly of the polymeric nanoparticles comprises encapsulation of the hydrophobic active in the polymeric nanoparticles.
Dependencies are inferred from the claim text.