Non-invasive passive interstitial fluid collector
AssigneeGeorgetown University
InventorMakarand Paranjape
Life of this patent
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Abstract
A microfluidic device for non-invasively and passively accessing interstitial fluid from a patient includes a substrate containing multiple vertical micro channels therethrough, wherein at a first end of each of the multiple vertical micro channels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid; and wherein at a second end of each of the multiple vertical micro channels is a horizontal micro channel for receiving accessed interstitial fluid from a vertical micro channel and guiding the accessed interstitial fluid to a common collection port.
Claims14
A microfluidic device for non-invasively and passively accessing interstitial fluid from an individual, the microfluidic device comprising:
- a substrate comprising layers of both poly(dimethylsiloxane) (PDMS) and polyimide, the substrate containing multiple vertical microchannels therethrough, wherein at a first end of each of the multiple vertical microchannels a microheater is formed for controllably ablating a portion of dry dead skin cells to access the interstitial fluid;
- and
- further wherein at a second end of each of the multiple vertical microchannels is a horizontal microchannel for receiving accessed interstitial fluid from at least one of the vertical microchannels and guiding the accessed interstitial fluid to a common collection port, wherein an angle between each of the multiple vertical microchannels and a corresponding horizontal microchannel is less than 90 degrees.
A microfluidic device for non-invasively and passively accessing interstitial fluid from an individual, the microfluidic device comprising:
- a first layer formed of polyimide;
- a second layer formed of poly(dimethylsiloxane) (PDMS), wherein the first and second layer are bonded together;
- an array of vertical microchannels formed through the first and second layer;
- at least one electrically controllable microheater formed at a polyimide end of each of the vertical microchannels;
- and
- a horizontal microchannel fluidly connected at a PDMS end of each vertical microchannel in the array of vertical microchannels for directing the interstitial fluid to a collection port, wherein an angle between each of vertical microchannel and a corresponding horizontal microchannel is less than 90 degrees.
Dependencies are inferred from the claim text.