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US 11,532,406 B2Granted
High specific activity preparation of F-18 tetrafluoroborate
AssigneeMayo Foundation for Medical Education and Research
InventorsTimothy R. DeGrado, Huailei Jiang
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Abstract
Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.
Claims9
A method of radiolabeling tetrafluoroborate (TFB) with 18F-fluoride, the method comprising:
- (a) trapping 18F-fluoride on an anion exchange column;
- (b) reacting 18F-fluoride with boron trifluoride (BF3);
- and
- (c) isolating the 18F-TFB from unreacted 18F-fluoride and BF3 from the anion exchange column, wherein the resultant 18F-TFB has a specific activity of at least 5 GBq/μmol.
1 more element
Dependencies are inferred from the claim text.