Collagen type X alpha-1 assay
AssigneeNordic Bioscience A/S
InventorsAnne Christine Bay-Jensen, Yi He, Morten Karsdal
Life of this patent
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Abstract
An antibody specifically reactive with an epitope of collagen type X alpha 1 comprised in the NC1 domain C-terminal amino acid sequence SFSGFLVAPM-COOH (SEQ ID NO: 1), and a method of immunoassay for detecting in a biological sample an epitope in the NC1 domain C-terminal amino acid sequence SFSGFLVAPM-COOH (SEQ ID NO: 1) of collagen type X alpha 1, by contacting the biological sample with the antibody, and determining the amount of binding of the antibody.
Claims8
A monoclonal antibody that comprises a light chain comprising complementarity-determining regions (CDRs) with amino acid sequences of SEQ ID NOS:
- 6-8 and a heavy chain comprising CDRs with amino acid sequences of SEQ ID NOS:
- 9-11, wherein said monoclonal antibody specifically binds to an NC1 domain C-terminal amino acid sequence SFSGFLVAPM-COOH (SEQ ID NO:
- 1) of human collagen type X alpha 1.
Dependencies are inferred from the claim text.