US 11,531,023 B2 · Biomarker for diagnosing overactive bladder disease and screening method of therapeutic agents using the same

Abstract

The present invention relates to a biomarker for diagnosis of overactive bladder (OAB) disease, and a method for screening a drug using the biomarker. The markers described in the present invention can effectively detect or diagnose the onset of OAB by distinguishing them from normal populations. In particular, OAB-specific protein markers released into urine enable simple and rapid OAB diagnosis in a non-invasive manner. In addition, by selecting an agent that changes, particularly normalizes the expression and activity of the markers selected in the present invention, more effective preventative or therapeutic agents of OAB disease can be screened.

Claims6

Dependent claims

A method for diagnosing and treating overactive bladder disease in a subject, the method comprising:

(a) obtaining a biological sample from a suspected subject of overactive bladder disease,
(b) measuring the expression level of EIF4B(Eukaryotic translation initiation factor 4B) in the biological sample;
(c) diagnosing the subject with overactive bladder disease when the expression or detection level of EIF4B from the biological sample is greater than that of a normal control sample;
and
(d) treating the diagnosed subject by administering an effective amount of a therapeutic agent for overactive bladder disease.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/169,020Filed 24 Oct 2018

Priority

KR 10-2018-004581319 Apr 2018

Published

US 2019/0324015 A124 Oct 2019

Granted

20 Dec 2022

Term ends

Not estimatedThe source records don’t support an estimate.

Classification24 codes

G01N 33/5023
For testing non-proliferative effects: on expression patterns
A61K 31/7088
Carbohydrates; Sugars; Derivatives thereof: compounds having three or more nucleosides or nucleotides
C07K 16/18
Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies: against material from animals or humans
C07K 16/28
Against material from animals or humans: against receptors, cell surface antigens or cell surface determinants

Biomarker for diagnosing overactive bladder disease and screening method of therapeutic agents using the same

Life of this patent

Biomarker for diagnosing overactive bladder disease and screening method of therapeutic agents using the same

Life of this patent

Abstract

Claims6