Humanized antibodies with ultralong complementary determining regions

A bovinized human antibody comprising:

• (a) a heavy chain variable domain comprising, in order:
• (i) amino acids 1-95 of the amino acid sequence of SEQ ID NO:
• 33, wherein SEQ ID NO:
• 33 comprises the following amino acid substitutions:
• Q5R, Q6E, G31D, Y32K, and E505, wherein up to 5 additional amino acids may be substituted excluding positions 5, 6, 31, 32 and 50 of SEQ ID NO:
• 33;
• and
• (ii) an ultralong CDR3 that is at least 35 amino acids in length;
• and
• (iii) a framework region 4 (FR4);
• and
• (b) a light chain variable domain.”