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US 11,530,439 B2Granted
Polymethine compounds and their use as fluorescent labels
AssigneeIllumina Cambridge Limited
InventorsAntoine Francais, Xiaohai Liu
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
Claims20
A compound of the formula (I), or a mesomeric form thereof:
- wherein mCat+ or mAn− is an organic or inorganic positively/negatively charged counterion;
- m is 0, 1, 2 or 3;
- p is 1 or 2;
- q is 1, 2, 3 4 or 5;
- alk is a chain of 1-5 carbon atoms optionally containing one or more double or triple bonds;
- Y is CH2;
- Z is OH;
- n is 0, 1, 2 or 3;
- X is OH or O−, or an amide or ester conjugate thereof;
- each of Ra1 and Ra2 is independently H, SO3−, sulfonamide, halogen, or a further ring fused to an adjacent carbon atom;
- and
- each of Rc1 and Rc2 is independently alkyl or substituted alkyl, wherein at least one of Ra1 or Ra2 is SO3−, or Ra1 or Ra2 is a further ring fused to an adjacent carbon atom, the further ring having an SO3−, or Rc1 or Rc2 is an alkyl sulfonic acid group.
9 more elements
Dependencies are inferred from the claim text.