Multiplex end-tagging amplification of nucleic acids

A method of DNA amplification comprising

• contacting genomic DNA with a library of transposomes with each transposome of the library having two transposases and two transposon DNA, wherein each transposon DNA includes a transposase binding site and a primer binding site sequence, wherein the primer binding site sequence is different from the primer binding site of other members of the transposome library, and wherein each transposome within the library of transposomes includes two different primer binding site sequences,
• wherein the library of transposomes bind to target locations along the genomic DNA and the transposase cleaves the genomic DNA into a plurality of double stranded genomic DNA fragments representing a genomic DNA fragment library, with each double stranded genomic DNA fragment includes a unique and/or different primer binding site sequence on each end of the genomic DNA fragment,
• filling a gap between the transposon DNA and the genomic DNA fragment to form a library of double stranded genomic DNA fragment extension products having unique and/or different primer binding site sequences at each end, and
• amplifying the double stranded genomic DNA fragment extension products to produce amplicons.