System and method for producing a therapeutic oligomer
AssigneeSachi Bioworks Inc.
InventorPrashant Nagpal
Life of this patent
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Abstract
A system for producing a therapeutic oligomer includes a computing device configured to design a proposed therapeutic oligomer sequence, wherein designing further comprises generating a genomic library for an organism from a gene target, initiating a sequence identification function, identifying a genomic locus that the proposed therapeutic oligomer sequence is predicted to bond to as a function of an off-target sequence function, selecting the proposed therapeutic oligomer sequence as a function of the sequence identification function, the genomic locus, and a criterion element, and synthesize a therapeutic oligomer as a function of the proposed therapeutic oligomer sequence.
Claims19
A method for producing a therapeutic oligomer, the method comprising:
- designing, by a computing device, a proposed therapeutic oligomer sequence, wherein designing further comprises:
- generating a genomic library for an organism from a plurality of gene targets;
- initiating a sequence identification function, wherein initiating further comprises:
- identifying a plurality of prospective gene targets as a function of the genomic library;
- and
- generating a proposed therapeutic oligomer sequence as a function of the plurality of prospective gene targets and an oligomeric machine learning model, wherein the oligomeric machine learning model is trained as a function of an oligomeric training set that correlates the plurality of prospective gene targets to an oligomer that regulates a gene expression;
- identifying a genomic locus that the proposed therapeutic oligomer sequence is predicted to bond to as a function of an off-target sequence function, wherein identifying the genomic locus further comprises:
- identifying an incidental alignment as a function of the proposed therapeutic oligomer sequence and the genomic library;
- modeling the incidental alignment to a corresponding genome assembly location as a function of aligning the proposed therapeutic oligomer sequence to a corresponding genome assembly location;
- identifying the genomic locus as a function of the incidental alignment model and an overlap element;
- and
- selecting the proposed therapeutic oligomer sequence as a function of the sequence identification function, the genomic locus, and a criterion element;
- and
- synthesizing, by the computing device, a therapeutic oligomer as a function of the proposed therapeutic oligomer sequence.
A system for producing a therapeutic oligomer, wherein the system comprises a computing device configured to:
- design a proposed therapeutic oligomer sequence, wherein designing further comprises:
- generating a genomic library for an organism from a plurality of gene targets;
- initiating a sequence identification function, wherein initiating further comprises:
- identifying a plurality of prospective gene targets as a function of the genomic library;
- and
- generating a proposed therapeutic oligomer sequence as a function of the plurality of the prospective gene targets and an oligomeric machine learning model, wherein the oligomeric machine learning model is trained as a function of an oligomeric training set that correlates the plurality of prospective gene targets to an oligomer that regulates a gene expression;
- identifying a genomic locus that the proposed therapeutic oligomer sequence is predicted to bond to as a function of an off-target sequence function, wherein identifying the genomic locus further comprises:
- identifying an incidental alignment as a function of the proposed therapeutic oligomer sequence and the genomic library;
- modeling the incidental alignment to a corresponding genome assembly location as a function of aligning the proposed therapeutic oligomer sequence to a corresponding genome assembly location;
- identifying the genomic locus as a function of the incidental alignment model and an overlap element;
- selecting the proposed therapeutic oligomer sequence as a function of the sequence identification function, the genomic locus, and a criterion element;
- and
- synthesize a therapeutic oligomer as a function of the proposed therapeutic oligomer sequence.
Dependencies are inferred from the claim text.