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AssigneesUniversity of Massachusetts, The Governing Council of the University of Toronto
InventorsErik J. Sontheimer, Alan Davidson, Karen Maxwell, April Pawluk, Yan Zhang, Jooyoung Lee, Nadia Amrani
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The present invention is related to the field of CRISPR-Cas9 gene editing platforms. In particular, the present invention has identified Type II-C Cas9 anti-CRISPR (Acr) inhibitors that control Cas9 gene editing activity. Co-administration of such Acr inhibitors may provide an advantageous adjunct in permitting safe and practical biological therapeutics through spatial or temporal control of Cas9 activity; controlling Cas9-based gene drives in wild populations to reduce the ecological consequences of such forced inheritance schemes; and contributing to general research into various biotechnological, agricultural, and medical applications of gene editing technologies.
A Type II-C anti-CRISPR (Acr) fusion protein comprising an adduct.
A composition comprising a Type II-C Cas9 protein comprising a binding site and a Type II-C anti-CRISPR (Acr) fusion protein comprising an adduct, wherein said Acr protein binds with specific affinity to said binding site.
Dependencies are inferred from the claim text.