Use of volatile compounds to modulate the perception of musk

#The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subject's perception of musk compounds, methods for intensifying a subject's perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).

#Musk compounds span chemically diverse families of molecules that generate a scent that is highly appreciated in perfumery.

#The intensity of the musk scent perceived by a subject is dependent on several factors, such as, but not limited to, the concentration of the musk compound in the perfumed article or perfuming composition, the subject's ability to perceive the musk scent, the efficacy and the affinity to the musk compound for musk olfactory receptors, the particular musk olfactory receptors present in the subject, and the like.

#FIG. 1 shows the correlation between musk-induced in vitro levels of OR5AN1 activation recordings for a series of distinct musks (a), and the overall increasing human sensitivities as shown by odor detection threshold recordings of the corresponding musks (b).

#FIG. 2 shows the result of a single point binary mixture of MUSCENONE® and perfumery raw materials screening for OR5AN1 Musk-induced activity enhancement.

#FIG. 3 shows the dose response curves of OR5AN1 to all four of agonist Muscone, MUSCENONE®, Musk X and Musk ketone in the presence and absence of tridecylenic aldehyde, and a dose-response to tridecylenic aldehyde alone.

#In the following description, reference is made to specific embodiments which may be practiced, which is shown by way of illustration. These embodiments are described in detail to enable those skilled in the art to practice the invention described herein, and it is to be understood that other embodiments may be utilized and that logical changes may be made without departing from the scope of the aspects presented herein. The following description of example embodiments is, therefore, not to be taken in a limited sense, and the scope of the various aspects presented herein is defined by the appended claims.

#The Abstract is provided to comply with 37 C.F.R. § 1.72(b) to allow the reader to quickly ascertain the nature and gist of the technical disclosure. The Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

#Olfactory receptors (OR) are seven-transmembrane members of the large G-protein coupled receptor (GPCR) family and thus exhibit most pharmacological characteristics of the GPCR receptor family. The present disclosure provides volatile compounds that can be used in perfumery applications to modulate, that is, enhance desired fragrances, such as, for example, a musk odor. In some aspects, volatile compounds that enhance the musk odor are positive allosteric modulators of a musk olfactory receptor. Without intending to be limited to any particular theory, synergistic interaction between perfumery ingredients can lead to more sensitive and more intense perception of perfumery tonalities. Such compounds thus enable new routes to optimize perfumery rules and create better performing commercial perfumery formulations.