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US 11,530,302 B2Granted
Method to prepare a filler with a hyaluronic acid base using specific crosslinking agents
AssigneeMatex Lab S.P.A.
InventorNicola Zerbinati
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Abstract
The present invention concerns a method to prepare a filler with a hyaluronic acid, which has improved properties of chemical-physical stability over time and optimal viscosity for cutaneous injection. In particular the method comprises a first step in which the hyaluronic acid is crosslinked, and a subsequent step for the neutralization and hydration of the crosslinked hyaluronic acid.
Claims10
A method to prepare of preparing a filler with a hyaluronic acid base comprising the crosslinking of the hyaluronic acid by means of the following steps:
- A1) mixing the following components in a reaction chamber equipped with a mixer to obtain a mixture:
- water, hyaluronic acid (HA), a crosslinking agent selected from the class of polyethylene glycols (PEG), and a solution of alkali metal hydroxide;
- A2) dividing the mixture thus obtained into a number n of partial portions and transferring said partial portions to a sequence of n containers to subject the partial portions of mixture to an ultrasound treatment, the number n of partial portions and containers being 4 to 32;
- and,
- A3) disposing the n containers comprising said partial portions of mixture in an incubator for a period of time of 4 to 8 hours to terminate crosslinking of hyaluronic acid (HA) and promote formation of a gel of crosslinked hyaluronic acid (HA).
2 more elements
Dependencies are inferred from the claim text.