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US 11,530,301 B2Granted
Carbohydrate crosslinker
AssigneeGalderma Holding SA
InventorsHotan Mojarradi, Johan Olsson, Craig Steven Harris, Jean-Guy Boiteau, Thibaut Gerfaud, Loïc Tomas
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Abstract
The invention relates to a hydrogel product comprising glycosaminoglycan molecules as the swellable polymer, wherein the glycosaminoglycan molecules are covalently crosslinked via crosslinks comprising a spacer group selected from the group consisting of di-, tri-, tetra-, and oligosaccharides.
Claims11
A process of preparing a hydrogel product comprising crosslinked hyaluronic acid (HA) molecules, the process comprising:
- (a) activating carboxyl groups on the HA molecules with a coupling agent to form activated HA molecules;
- (b) crosslinking the activated HA molecules via their activated carboxyl groups using diaminotrehalose to obtain crosslinked HA molecules;
- and
- (c) hydrolyzing ester bonds in the crosslinked HA molecules via alkaline hydrolysis to obtain a hydrogel product having less than 50% non-crosslinked HA molecules by weight of the hydrogel product, and
- wherein the crosslinked HA molecules are free from synthetic non-carbohydrate structures and synthetic non-carbohydrate linkers.
2 more elements
Dependencies are inferred from the claim text.