Sulfobetaine-based protein aggregation inhibitor for use in preventing aggregation of a protein
AssigneesOsaka Organic Chemical Industry Ltd., Japan Advanced Institute of Science and Technology
InventorsKazuaki Matsumura, Rajan Robin, Yoko Taniyama, Yoshiyuki Saruwatari
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Abstract
The present invention provides a protein aggregation inhibitor for use in preventing aggregation of a protein, containing a crosslinked polymer obtained by polymerizing polymerizable polymer components containing a sulfobetaine polymer obtained by polymerizing monomer components containing a sulfobetaine monomer, the sulfobetaine monomer, and a crosslinkable monomer.
Claims6
A protein aggregation inhibitor for use in preventing aggregation of a protein, the inhibitor comprising a crosslinked polymer obtained by polymerizing polymerizable polymer components comprising
- a sulfobetaine polymer obtained by polymerizing monomer components comprising a sulfobetaine monomer,
- the sulfobetaine monomer, and
- a crosslinkable monomer,
- wherein the sulfobetaine monomer is represented by the formula (I):
- wherein R1 is a hydrogen atom or a methyl group, R2 is an alkylene group having 1-4 carbon atoms, R3 is an alkyl group having 1-4 carbon atoms, R4 is an alkylene group having 1-4 carbon atoms, and X is an —NH— group or an —O— group.
A method of producing a protein aggregation inhibitor for use in preventing aggregation of a protein and comprising a crosslinked polymer, the method comprising
- polymerizing monomer components comprising a sulfobetaine monomer, and
- polymerizing polymerizable polymer components comprising the resulting sulfobetaine polymer, the sulfobetaine monomer, and a crosslinkable monomer,
- wherein the sulfobetaine monomer is represented by the formula (I):
- wherein R1 is a hydrogen atom or a methyl group, R2 is an alkylene group having 1-4 carbon atoms, R3 is an alkyl group having 1-4 carbon atoms, R4 is an alkylene group having 1-4 carbon atoms, and X is an —NH— group or an —O— group.
Dependencies are inferred from the claim text.