DPP3 binder directed to and binding to specific DPP3-epitopes and its use in the prevention or treatment of diseases / acute conditions that are associated with oxidative stress
Assignee4TEEN4 Pharmaceuticals GmbH
InventorAndreas Bergmann
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Abstract
The present invention provides binder directed to and binding to a DPP3 protein or functional derivative thereof and its use in a method of prevention or treatment of diseases or acute conditions in a patient, wherein said disease or acute condition is associated with oxidative stress. With this context, specifically the present invention provides a binder being directed to and binding to an epitope according to SEQ ID NO.: 2, wherein said epitope is comprised in a DPP3 protein or a functional derivative thereof, and wherein said DPP3 binder recognizes and binds to at least three amino acids of SEQ ID NO.: 2.
Claims6
A dipeptidyl peptidase 3 (DPP3) binder directed to and binding to an epitope according to SEQ ID NO.:
- 2, and wherein said DPP3 binder recognizes and binds to at least three amino acids of SEQ ID NO.:
- 2, wherein said epitope is comprised in SEQ ID NO.:
- 1, and wherein said DPP3 binder exhibit an affinity towards DPP3 in such that the affinity constant is at least 107 M−1,
- wherein said DPP3 binder is a monoclonal antibody or antigen binding fragment, and wherein the complementarity determining regions (CDR's) in the heavy chain comprises the sequences:
- SEQ ID NO.:
- 7, SEQ ID NO.:8 and SEQ ID NO.:
- 9
- And the complementarity determining regions (CDR's) in the light chain comprises the sequences:
- SEQ ID.:
- 10, KVS and SEQ ID NO.:
- 11.
Dependencies are inferred from the claim text.