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US 11,530,274 B2Granted
Anti-STEAP1 antigen-binding protein
AssigneesAmgen Inc., Xencor, Inc.
InventorsOlivier Nolan-Stevaux, Cong Li, Christopher M. Murawsky, Benjamin M. Alba, Neeraj Jagdish Agrawal, Kevin Graham, Jennitte LeAnn Stevens, Gregory Moore
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Abstract
The disclosure provides novel antigen-binding proteins that bind STEAP1 and methods of use.
Claims72
A bispecific antigen binding protein that binds STEAP1 of SEQ ID NO:
- 2 and comprises:
- (a) heavy chain CDRs comprising amino acid sequences set forth in vhCDR1 SEQ ID NO:
- 14, vhCDR2 SEQ ID NO:
- 15 or vhCDR2 SEQ ID NO:
- 21, and vhCDR3 SEQ ID NO:
- 16 and
- (b) light chain CDRs comprising amino acid sequences set forth in vlCDR1 SEQ ID NO:
- 11, vlCDR2 SEQ ID NO:
- 12, and vlCDR3 SEQ ID NO:
- 13.
7 more elements
A heterodimeric antibody comprising a first monomer comprising the sequence of SEQ ID NO:
- 202, a second monomer comprising the sequence of SEQ ID NO:
- 201, and a common light chain comprising the sequence of SEQ ID NO:200.
A heterodimeric antibody comprising a first monomer comprising the sequence of SEQ ID NO:
- 19, a second monomer comprising the sequence of SEQ ID NO:18, and a common light chain comprising the sequence of SEQ ID NO:17.
A heterodimeric antibody comprising a first monomer comprises the sequence of SEQ ID NO:
- 207, a second monomer comprising the sequence of SEQ ID NO:
- 203, and a common light chain comprising the sequence of SEQ ID NO:200.
Dependencies are inferred from the claim text.