Anti-CD73 monoclonal antibody, encoding nucleic acids and method for producing
AssigneeHelmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
InventorsReinhard Zeidler, Bettina Von Neubeck, Regina Feederle, Stefanie Hauck
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Abstract
The present invention relates to improved anti-CD73 antibodies which, in comparison to prior art anti-CD73 antibodies bind to a membrane-bound form of CD73 protein having cancer-promoting role and inhibit its enzymatic activity, while essentially not inhibiting a soluble form of CD73 protein involved in cardioprotection. The present invention further relates to methods of generation of such specific anti-CD73 antibodies and uses thereof including uses as medicaments and in methods for treatment, amelioration, prophylaxis and diagnostics of cancer.
Claims16
An anti-CD73 monoclonal antibody or antigen-binding portion thereof, wherein said anti-CD73 monoclonal antibody or antigen-binding portion thereof exhibits the following properties:
- i) A heavy chain variable region comprising Complementarity Determining Regions (CDRs) H-CDR1, H-CDR2 and H-CDR3 having the amino acid sequence of SEQ ID NOs:
- 10, 11 and 12 respectively;
- and
- ii) A light chain variable region comprising Complementarity Determining Regions (CDRs) L-CDR1, L-CDR2 and LCDR3 having the amino acid sequences of SEQ ID NOs:
- 14, 15 and 16 respectively.
Dependencies are inferred from the claim text.