Smart car devices, DE car polypeptides, side CARs and uses thereof
AssigneeChimera Bioengineering, Inc.
InventorsBenjamin Wang, Gusti Zeiner
Life of this patent
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Abstract
RNA Control Devices and/or destabilizing elements (DE) can regulate the expression of Chimeric Antigen Receptors (CARs) in eukaryotic cells. More specifically, DEs, RNA Control Devices, and/or side-CARs can be used with small molecule ligands to regulate the expression of Chimeric Antigen Receptors. These DE-CARs, Smart CARs (Smart=small molecule actuatable RNA trigger), Smart-DE-CARs, and/or Side-CARs can be used in the treatment of disease.
Claims5
An isolated T-cell comprising a promoter operably linked to a nucleic acid, wherein the nucleic acid comprises a polynucleotide encoding a degron operably linked to a polynucleotide encoding a chimeric antigen receptor.
An isolated cytotoxic T-cell comprising a promoter operably linked to a nucleic acid, wherein the nucleic acid comprises a polynucleotide encoding a degron operably linked to a polynucleotide encoding a chimeric antigen receptor.
Dependencies are inferred from the claim text.