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US 11,530,257 B2Granted
Chimeric antibodies for treatment of amyloid deposition diseases
OwnerTarran Jones, Alison Levy +1inventors
InventorsTarran Jones, Alison Levy, Siobhan O'Brien
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Abstract
A chimeric mouse-human antibody for treatment of amyloid deposition diseases, pharmaceutical compositions comprising the antibody, methods and materials for producing the antibody, and methods for treating an amyloid deposition disease using the antibody and the pharmaceutical composition.
Claims8
A chimeric mouse-human antibody for treating primary amyloidosis comprising a VK and VH region, wherein the VK region is SEQ ID NO:
- 47 and the VH region is SEQ ID NO:
- 48, wherein the chimeric antibody binds to amyloid fibrils with a higher affinity than its murine equivalent.
A polypeptide selected from SEQ. ID NO:
- 47 and SEQ. ID NO:
- 48.
Dependencies are inferred from the claim text.