Antibody specific to alpha-toxin of Staphylococcal aureus and uses thereof

An antibody or antigen-binding fragment thereof that specifically binds to an epitope in α-toxin of Staphylococcal aureus or a fragment thereof;

• wherein the antibody or antigen-binding fragment thereof comprises complementarity determining regions (CDRs) of a heavy chain variable region and complementarity determining regions of a light chain variable region, wherein the complementarity determining regions of the heavy chain variable region comprise CDRH1, CDRH2 and CDRH3 regions, and the complementarity determining regions of the light chain variable region comprise CDRL1, CDRL2 and CDRL3 regions, and wherein:
• the CDRH1 region comprises the amino acid sequence consisting of SEQ ID NO:
• 1;
• the CDRH2 region comprises the amino acid sequence consisting of SEQ ID NO:
• 3;
• the CDRH3 region comprises the amino acid sequence consisting of SEQ ID NO:
• 7;
• and
• the CDRL1 region comprises the amino acid sequence consisting of SEQ ID NO:
• 10;
• the CDRL2 region comprises the amino acid sequence consisting of SEQ ID NO:
• 14;
• the CDRL3 region comprises the amino acid sequence consisting of SEQ ID NO:
• 16.