Methods and compositions relating to chimeric antigen receptors
AssigneeTrustees of Boston University
InventorsWilson W. Wong, Jang Hwan Cho
Life of this patent
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Abstract
Described herein is a chimeric antigen receptor (CAR) platform with the ability to (a) serve as an ON/OFF switch (with the ability for tenability/titrability), (b) sense multiple antigens and perform logic computations, and/or (c) independently regulate multiple signaling pathways. The compositions provided herein permit the degree of control and discrimination necessary to optimize CAR T cell therapy. Also described herein are cells comprising such compositions and the use of these compositions and/or cells in the treatment of cancer.
Claims16
A composition comprising a multi-component chimeric antigen receptor (CAR);
- the multi-component CAR comprising:
- a. a first recognition polypeptide, which is an extracellular polypeptide comprising 1) an antibody reagent specific for a first target ligand and 2) a protein interaction domain;
- and
- b. a signaling polypeptide comprising 1) an extracellular protein interaction domain that can bind specifically with the protein interaction domain of the first recognition polypeptide, 2) a transmembrane domain, and 3) an intracellular T cell receptor (TCR) signaling domain;
- wherein the protein interaction domains are leucine zipper domains.
A composition comprising a multi-component chimeric antigen receptor (CAR);
- the multi-component CAR comprising:
- a. a first recognition polypeptide, which is an extracellular polypeptide comprising 1) an antibody reagent specific for a first target ligand and 2) a protein interaction domain;
- and
- b. a cell comprising a signaling polypeptide, which is a transmembrane polypeptide comprising 1) an extracellular protein interaction domain that can bind specifically with the protein interaction domain of the first recognition polypeptide and 2) an intracellular T cell receptor (TCR) signaling domain;
- wherein the protein interaction domains are leucine zipper domains.
A composition comprising a multi-component chimeric antigen receptor (CAR);
- the multi-component CAR comprising:
- a. a first recognition polypeptide, which is an extracellular polypeptide consisting of 1) an antibody reagent specific for a first target ligand and 2) a protein interaction domain;
- and
- b. a signaling polypeptide, which is a transmembrane polypeptide comprising 1) an extracellular protein interaction domain that can bind specifically with the protein interaction domain of the first recognition polypeptide and 2) an intracellular T cell receptor (TCR) signaling domain
- wherein the protein interaction domains are leucine zipper domains.
Dependencies are inferred from the claim text.