Cyclic polypeptides for PCSK9 inhibition

A polycyclic peptide of Formula (I):

• or a pharmaceutically acceptable salt thereof;
• wherein:
• X is selected from the group consisting of F, OH, Br, Me, OMe, CI, and CF3;
• A1 is H, an acyl protected amine,
• R1 is selected from the group consisting of the amino acid side chains of
• and TYR;
• R2 is selected from the group consisting of the amino acid side chains of ALA,
• THR, and VAL;
• R3 is selected from the group consisting of the amino acid side chains of ALA, ASP,
• and PRO;
• R4 is selected from the group consisting of the amino acid side chains of
• THR, and VAL;
• R5 is selected from the group consisting of the amino acid side chains of
• L1 is
• A2 is absent or
• P1 is selected from the group consisting of H, acetyl,
• wherein each amino acid residue is optionally an N-methylated amino acid;
• wherein each amino acid residue can be the R or S-enantiomer configuration;
• and
• n is 0, 1, 2, 3, or 4.