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US 11,530,243 B2Granted
Non-cleavable substance P conjugates and methods of use thereof
AssigneeVeiove Animal Health
InventorsDouglas A Lappi, Brian J Russell, E Denise Higgins
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Abstract
Described herein are methods for treating disorders that relate to neurons that express the neurokinin-1 receptor (NK-1R) in a subject which comprises administering to the subject an effective amount of the pharmaceutical composition of the non-cleavable conjugate comprising a molecule that is recognized and internalized by the NK-1R, and a molecule that is taken inside the cell to kill or temporarily alter the cell.
Claims4
A non-cleavable conjugate comprising:
- a) a substance P analog selected from the group consisting of Maleimidopropionic acid (MPA)GGGGGGRPKPQQFF SarLMet(O2)-amide (SEQ ID No.:1) and Maleimidopropionic acid (MPA)GGGGGGRPKPQQFFGLM-amide (SEQ ID No.:2);
- and
- b) a saporin, an analog or a fragment thereof, that is taken inside a cell to kill alter the cell, wherein said saporin, analog or fragment thereof, is linked to said substance P analog via MPA;
- and
- wherein said saporin, analog or fragment thereof maintains its cell altering activity.
2 more elements
Dependencies are inferred from the claim text.