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US 11,530,242 B2Granted
EGFRvIII immunogen and methods for using same
OwnerBryce Chackerian, Oliver Rixeinventors
Life of this patent
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Abstract
An immunogen includes an antigenic EGFRvIII peptide linked to a Qβ bacteriophage virus-like particle (VLP) carrier. The antigenic EGFRvIII peptide has at least 53%, at least 61%, at least 69%, at least 76%, at least 84%, or at least 92% sequence similarity amino acid similarity to LEEKKGNYVVTDH (SEQ ID NO:1).
Claims9
An immunogen comprising:
- an immunogenic carrier comprising a Qβ bacteriophage virus-like particle (VLP);
- and
- an antigenic EGFRvIII peptide comprising LEEKKGNYVVTDH (SEQ ID NO:1) linked to the immunogenic carrier.
A method of treating cancer in an individual, the method comprising administering a therapeutically effective amount of an immunogen to the individual, the immunogen comprising:
- an immunogenic carrier comprising a Qβ bacteriophage virus-like particle (VLP);
- and
- an antigenic EGFRvIII peptide comprising LEEKKGNYVVTDH (SEQ ID NO:1) linked to the immunogenic carrier.
Dependencies are inferred from the claim text.