Catheter injectable cyclic peptide pro-gelators for myocardial tissue engineering
AssigneeThe Regents of the University of California
InventorsNathan C. Gianneschi, Karen L. Christman, Andrea S. Carlini
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Abstract
Cyclic peptide pro-gelator compositions, and methods of therapeutic use, which assemble into macromolecular hydrogel when administered through cleavage by endogenous enzymes upregulated at a site of tissue injury, such as a myocardial infarction.
Claims18
A tissue scaffolding composition comprising a pharmaceutically acceptable carrier and a cyclic peptide having a substrate recognition sequence that when enzymatically cleaved linearizes and self-assembles with like-kind peptides into a hydrogel, wherein the cyclic peptide is disulfide bonded by terminal cysteine residues and comprises repeating amino acid sequence KFDF (SEQ ID NO:1) and wherein the peptide self-assembles into a hydrogel via beta-sheets.
A method of creating a scaffold for tissue repair in a patient in need thereof comprising administering to the patient a cyclic peptide having a substrate recognition sequence that when enzymatically cleaved linearizes and self-assembles with like-kind peptides into a hydrogel, wherein the cyclic peptide has a disulfide bonded by terminal cysteine residues and comprises repeating amino acid sequence KFDF (SEQ ID NO:1) and wherein the peptide self-assembles into a hydrogel via beta-sheets.
A peptide comprising the amino acid sequence CKFDFKFDFKFDFPLGLAGC (SEQ ID NO:7).
Dependencies are inferred from the claim text.