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US 11,530,233 B2Granted
Beta-nicotinate ester nucleotides and processes for preparing same
AssigneeCornell University
InventorAnthony A. Sauve
Life of this patent
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Abstract
The invention provides a compound of formula (I): wherein R is as described herein. The invention also provides a process for the preparation of the compound.
Claims24
A process for the preparation of a compound of formula (I):
- wherein R is straight or branched chain C3-C20 alkyl, straight or branched chain C3-C20 alkenyl, C3-C20 alkynyl, C3-C20 cycloalkyl, C6-C10 aryl, C3-C20 heterocyclyl, or C5-C10 heteroaryl, or a salt thereof, wherein R is substituted or unsubstituted, and wherein the process comprises the step of reacting a compound of formula (III):
- with a mixture of POCl3 and PO(OR5)3, wherein R5 is C1-C6 alkyl, followed by isolation of the compound of formula (I).
A compound of formula (I):
- wherein R is n-propyl, n-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, 2,2-dimethylpropyl, 3-methylbutyl, isopropyl, 1,1-dimethylpropyl, t-butyl, substituted or unsubstituted morpholine, substituted or unsubstituted piperidine, substituted or unsubstituted tetrahydrofuryl, substituted or unsubstituted oxetanyl, substituted or unsubstituted pyrrolidinyl, or substituted or unsubstituted dihydrobenzofuran, or a salt thereof.
Dependencies are inferred from the claim text.