Cyano cyclobutyl compounds for CBL-B inhibition and uses thereof

A compound of Formula (I)

• or a tautomer thereof, stereoisomer thereof, or a pharmaceutically acceptable salt thereof,
• wherein
• Z1 is CH or nitrogen;
• Z2 is CH or nitrogen;
• R1 is hydrogen, C1-C6 alkyl, or C1-C6 haloalkyl;
• R2 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, or C3-C6 cycloalkyl;
• R3 is —CF3 or cyclopropyl;
• R4 is —CF3 or cyclopropyl;
• X is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, or
• R5 is hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyl-OH, or C1-C6 alkyl-CN;
• R6 is monocyclic C3-C6 cycloalkyl, fused bicyclic C4-C8 cycloalkyl, bridged bicyclic C4-C8 cycloalkyl, spiro bicyclic C5-C8 cycloalkyl, or 5- to 6-membered heterocyclyl, each of which is optionally substituted by one to five R7 groups;
• or R5 and R6 are taken together with the nitrogen atom to which they are attached to form a 5- to 10-membered monocyclic, fused bicyclic, or bridged heterocyclyl, or a 5- to 10-membered monocyclic or bicyclic heteroaryl, each of which heterocyclyl or heteroaryl optionally contains one to two additional heteroatoms selected from the group consisting of nitrogen and oxygen, and each of which heterocyclyl or heteroaryl is optionally substituted by one to five R8 groups;
• each R7 is independently halo, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyl-OH, or C1-C6 alkyl-CN;
• each R8 is independently C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkyl-OH, —CN, C1-C6 alkyl-CN, —(C1-C6 alkylene)-O—(C1-C6 alkyl), hydroxy, or halo,
• or two R8 groups attached to the same carbon atom are taken together with the carbon atom to which they are attached to form a spiro C3-C6 cycloalkyl or a spiro 5- to 6-membered heterocyclyl;
• each R9 is independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, or C1-C6 alkyl-OH;
• and
• n is zero or one.