Pyrimido[4,5-d]pyrimidin-2-one derivatives as protein kinase inhibitors

A compound selected from a pyrimido[4,5-d]pyrimidin-2-one derivative compound represented by any one of the following Formulae 1 to 6, a pharmaceutically acceptable salt thereof, a hydrate thereof and a stereoisomer thereof:

• wherein
• R1 is hydrogen;
• a C1-C13 alkyl group;
• a C3-C10 cyclic group;
• or a C3-C10 heterocyclic group;
• A is hydrogen;
• a C1-C13 alkyl group;
• a C6-C10 aryl group;
• a C3-C10 cyclic group;
• a C3-C10 heteroaryl group;
• a C3-C10 heterocyclic group;
• or —C(O)—C1-C13 alkyl);
• Y is a C6-C10 aryl group;
• or a 5-membered to 9-membered heteroaryl group containing one to four heteroatoms selected from nitrogen (N), oxygen (O) and sulfur (S) atoms;
• L1, L2, L3 and L4 are each independently selected from the group consisting of —NR5—;
• —NR5CH2—;
• —NR5CO)—;
• —C(O)NR5—;
• —NR5C(O)NR5—;
• —S(O)2—;
• —NR5S(O)2—;
• —S(O)2NR5—;
• —O—;
• —CH2—;
• —CH(CH3)—;
• —C(O)O—;
• —C(O)—;
• L5 and L6 are each independently —C(O)NR5R6;
• —CR5R6R7;
• —OR5;
• —CCl3;
• a C1-C6 alkyl group;
• a C3-C10 cyclic group;
• -substituted or unsubstituted benzene;
• -substituted or unsubstituted indole;
• -substituted or unsubstituted phenyl;
• -substituted or unsubstituted hexane;
• -substituted or unsubstituted furan;
• -substituted or unsubstituted thiophene;
• -substituted or unsubstituted pyridine;
• -substituted or unsubstituted benzofuran;
• -substituted or unsubstituted naphthalene;
• -substituted or unsubstituted anthracene;
• or -substituted or unsubstituted phenathrene;
• R2, R3 and R4 are each independently —O—;
• —CH2—;
• —CH(CH3)—;
• —CR5R6—;
• —NR5—;
• —NR5CH2—;
• —NR5C(O)—, —C(O)NR5—;
• —NR5C(O)NR5—;
• —S(O)2—;
• —NR5S(O)2—;
• or —C3-C10 cyclic group-;
• R5, R6 and R7 are each independently hydrogen;
• halogen;
• a C1-C6 alkyl group;
• a C3-C10 cyclic group;
• a C6-C10 aryl group;
• or —CH2(Ph);
• R10, R11 and R12 are each independently hydrogen;
• a C1-C13 alkyl group;
• a C6-C10 aryl group;
• a C3-C10 cyclic group;
• a C3-C10 heteroaryl group;
• a C3-C10 heterocyclic group;
• —C(O)—(C1-C13 alkyl);
• —CH2(Ph), —CH2(Ph)R5;
• a benzyl group;
• or —CH2CH═CH2;
• and
• N is 0, 1, 2, 3 or 4,
• wherein the C1-C6 alkyl group, C1-C13 alkyl group or C3-C10 cyclic group includes at least one substituent selected from the group consisting of hydrogen;
• a hydroxy group;
• a halogen group;
• a C1-C13 alkyl group;
• a C1-C6 alkoxy group;
• an amino group (—NR8R9);
• a nitro group (—N(O)2);
• an amide group (—(C═O)NR8R9);
• a carboxylic group (—C(O)OH), a nitrile group (—CN), a urea group (—NR8(C═O)NR9—);
• a sulfonamide group (—NHS(O)2—);
• a sulfide group (—S—);
• a sulfone group (—S(O)2—);
• a phosphoryl group (—P(O)R8R9);
• a C6-C10 aryl group;
• a C3-C10 heteroaryl group;
• and a C3-C10 heterocyclic group,
• the C6-C10 aryl group, C3-C10 heteroaryl group or C3-C10 heterocyclic group includes at least one substituent selected from the group consisting of hydrogen;
• a hydroxy group;
• a halogen group;
• a carbonyl group (—(C═O)R8R9);
• a C1-C3 alkyl group substituted or unsubstituted with halogen or a C3-C10 heterocyclic group;
• a C1-C3 alkoxy group substituted or unsubstituted with halogen or a C3-C10 heterocyclic group;
• C6-C10 phenoxy;
• an amino group (—NR8R9);
• a nitro group (—N(O)2);
• an amide group (—(C═O)NR8R9);
• a carboxylic group (—C(O)OH), a nitrile group (—CN), a urea group (—NR8(C═O)NR9—);
• a sulfonamide group (—NHS(O)2—);
• a sulfide group (—S—);
• a sulfone group (—S(O)2—);
• a phosphoryl group (—P(O)R8R9);
• a C6-C10 aryl group;
• a C3-C10 heteroaryl group;
• and a C3-C10 heterocyclic group,
• R8 and R9 described above include at least one selected from the group consisting of hydrogen;
• a C1-C6 alkyl group;
• a C1-C6 alkenyl group;
• a C1-C6 alkynyl group;
• a C6-C10 aryl group;
• a C3-C10 heteroaryl group;
• and a C3-C10 heterocyclic group, and
• the C3-C10 heteroaryl group and the C3-C10 heterocyclic group include at least one heteroatom selected from the group consisting of N, O, and S.